1. Protein Tyrosine Kinase/RTK
  2. Src

Lck inhibitor 2 

Cat. No.: HY-10644 Purity: 99.73%
Handling Instructions

Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively

For research use only. We do not sell to patients.

Lck inhibitor 2 Chemical Structure

Lck inhibitor 2 Chemical Structure

CAS No. : 944795-06-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 370 In-stock
Estimated Time of Arrival: December 31
5 mg USD 336 In-stock
Estimated Time of Arrival: December 31
10 mg USD 432 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1164 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Lck inhibitor 2:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively IC50 Value: 13 nM(Lck) [1] Target: Src family kinase Lck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM)[2].

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (59.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9819 mL 14.9094 mL 29.8187 mL
5 mM 0.5964 mL 2.9819 mL 5.9637 mL
10 mM 0.2982 mL 1.4909 mL 2.9819 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (5.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (5.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (5.96 mM); Clear solution

References
Molecular Weight

335.36

Formula

C₁₈H₁₇N₅O₂

CAS No.

944795-06-6

SMILES

OC1=CC=C(C)C(NC2=CC=NC(NC3=CC(C(N)=O)=CC=C3)=N2)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.73%

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
Lck inhibitor 2
Cat. No.:
HY-10644
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Lck inhibitor 2

Cat. No.: HY-10644