1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Lenalidomide-C9-aldehyde

Lenalidomide-C9-aldehyde 

Cat. No.: HY-130987
Handling Instructions

Lenalidomide-C9-aldehyde is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-C9-aldehyde can be used in the synthesis of a series of PROTACs, such as INY-03-041 (HY-133120). INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.

For research use only. We do not sell to patients.

Lenalidomide-C9-aldehyde Chemical Structure

Lenalidomide-C9-aldehyde Chemical Structure

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Description

Lenalidomide-C9-aldehyde is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-C9-aldehyde can be used in the synthesis of a series of PROTACs, such as INY-03-041 (HY-133120). INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].

IC50 & Target[1]

Cereblon

 

In Vitro

Lenalidomide is a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1].

Molecular Weight

398.50

Formula

C₂₃H₃₀N₂O₄

SMILES

O=C(C(N(CC1=C2C=CC=C1CCCCCCCCCC=O)C2=O)CC3)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lenalidomide-C9-aldehydeE3 Ligase Ligand-Linker ConjugatealkyletherGDC-0068LenalidomideINY-03-041AktdegraderInhibitorinhibitorinhibit

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Product name:
Lenalidomide-C9-aldehyde
Cat. No.:
HY-130987
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