2. Metabolic Enzyme/Protease Autophagy
  3. Cytochrome P450 Autophagy
  4. Letrozole

Letrozole  (Synonyms: CGS 20267)

Cat. No.: HY-14248 Purity: 99.92%
COA Handling Instructions

Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer.

For research use only. We do not sell to patients.

Letrozole Chemical Structure

Letrozole Chemical Structure

CAS No. : 112809-51-5

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Solution
10 mM * 1 mL in DMSO USD 87 In-stock
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200 mg USD 85 In-stock
500 mg USD 100 In-stock
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Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of Letrozole:

Letrozole Related Antibodies

Top Publications Citing Use of Products

    Letrozole purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Jun;15(6):5269-5274.  [Abstract]

    Letrozole significantly increases the protein levels of Ras/ERK1/c-Myc in the classical MAPK pathway.

    Letrozole purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Jun;15(6):5269-5274.  [Abstract]

    Detection of the effects of Letrozole and the MAPK pathway on the proliferation of GC-1 spg cells by BrdU. MAPK, mitogen-activated protein kinase; spg, spermatogonia; BrdU, bromodeoxyuridine.

    View All Cytochrome P450 Isoform Specific Products:

    View All Isoforms
    CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 CYP19 CYP26 CYP51

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].

    IC50 & Target

    Aromatase

     

    In Vitro

    Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner[2].
    Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation[2].
    Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Letrozole Related Antibodies

    Cell Viability Assay[2]

    Cell Line: MCF-7 cells
    Concentration: 0.1, 1, 10, 100 nM
    Incubation Time: 24, 48, 96 hours
    Result: Inhibited cells growth in a dose- and time-dependent manner.
    In Vivo

    Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult female rats bearing mammary tumors[3]
    Dosage: 3, 10, 30, 100, 300 μg/kg
    Administration: Oral gavage once daily for 6 weeks
    Result: Induced complete regression of mammary tumors, with an ED50 of 10-30 μg/kg/day.
    Clinical Trial
    Molecular Weight

    285.30

    Appearance

    Solid

    Formula

    C17H11N5
    CAS No.
    SMILES

    N#CC1=CC=C(C(N2C=NC=N2)C3=CC=C(C#N)C=C3)C=C1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (175.25 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5051 mL 17.5254 mL 35.0508 mL
    5 mM 0.7010 mL 3.5051 mL 7.0102 mL
    10 mM 0.3505 mL 1.7525 mL 3.5051 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.92%

    COA (248 KB) HNMR (236 KB) LCMS (265 KB)

    Handling Instructions (2659 KB)
    References
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    • If you have published this work, please enter the PubMed ID.
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    Letrozole Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Letrozole112809-51-5CGS 20267CGS20267CGS-20267Cytochrome P450AutophagyCYPsaromataseestrogenbreastcancerInhibitorinhibitorinhibit

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