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Products are for research use only. Not for human use. We do not sell to patients.
(Encorafenib; LGX 818; LGX-818)
LGX818 Chemical Structure
|Product name: LGX818|
|Cat. No.: HY-15605|
LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
IC50 value: 0.3 nM (BRaf V600E biochemical); 2 nM (A375 cell proliferation) 
Target: mutated BRaf V600E
LGX818 is a drug candidate for the treatment of melanoma with the V600E mutation in the B-RAF kinase. The substance is being developed by Novartis, is in phase III clinical trials, and was disclosed at the spring 2013 American Chemical Society meeting in New Orleans. More information can be found in Patent WO2011025927A1
|M.Wt||540.01||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||1.8518 mL||9.2591 mL||18.5182 mL|
|5 mM||0.3704 mL||1.8518 mL||3.7036 mL|
|10 mM||0.1852 mL||0.9259 mL||1.8518 mL|
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