1. Metabolic Enzyme/Protease
  2. LXR
  3. LXR antagonist 2

LXR antagonist 2 

Cat. No.: HY-146289
Handling Instructions

LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, with IC50 values of 0.36 and 2.25 μM for LXRβ and LXRα, respectively. LXR antagonist 2 is a lipogenesis inhibitor through down-regulating LXR target genes SREBP-1c, ACC, FAS and SCD-1. LXR antagonist 2 shows lipid-lowering effects in mice with Triton WR-1339-induced hyperlipidemia.

For research use only. We do not sell to patients.

LXR antagonist 2 Chemical Structure

LXR antagonist 2 Chemical Structure

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Description

LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, with IC50 values of 0.36 and 2.25 μM for LXRβ and LXRα, respectively. LXR antagonist 2 is a lipogenesis inhibitor through down-regulating LXR target genes SREBP-1c, ACC, FAS and SCD-1. LXR antagonist 2 shows lipid-lowering effects in mice with Triton WR-1339-induced hyperlipidemia[1].

IC50 & Target

IC50: 0.36 ± 0.05 μM (LXRβ) 2.25 ± 0.58 μM (LXRα)[1]

Molecular Weight

588.76

Formula

C34H40N2O5S

SMILES

CC([[email protected]]1N(CC[[email protected]]12C(N(C3=C2C=CC=C3)C4=CC=CC(C5=CC=C(C(S(C)(=O)=O)=C5)CO)=C4)=O)C(CC(C)(C)C)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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LXR antagonist 2
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HY-146289
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