1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  2. HSP
  3. Macbecin

Macbecin  (Synonyms: Macbecin I; NSC 330499)

Cat. No.: HY-107578
Handling Instructions

Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities.

For research use only. We do not sell to patients.

Macbecin Chemical Structure

Macbecin Chemical Structure

CAS No. : 73341-72-7

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Description

Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].

IC50 & Target

HSP90

2 μM (IC50)

HSP90

0.24 μM (Kd)

Molecular Weight

558.66

Formula

C30H42N2O8

CAS No.
SMILES

O=C(C(NC(/C(C)=C/C=C/[C@H](C)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H](OC)[C@@H](OC)C[C@@H]1C)=O)=C2)C([C@]1([H])OC)=CC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Macbecin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Macbecin
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