1. Metabolic Enzyme/Protease
    Anti-infection
  2. Phospholipase
    Bacterial
  3. Manoalide

Manoalide 

Cat. No.: HY-N7487
Handling Instructions

Manoalide is a potent Phospholipase A2 (PLA2) and Phospholipase C (PLC) inhibitor. Manoalide, a sesterpenoid compound, displays anti-inflammatory and antibacterial activities.

For research use only. We do not sell to patients.

Manoalide Chemical Structure

Manoalide Chemical Structure

CAS No. : 75088-80-1

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Description

Manoalide is a potent Phospholipase A2 (PLA2) and Phospholipase C (PLC) inhibitor. Manoalide, a sesterpenoid compound, displays anti-inflammatory and antibacterial activities[1][2][3].

IC50 & Target[1][2][3]

PLA2

 

PLC

 

In Vitro

Manoalide (0.05 μM) impaires IL-7-induced entry of the B cell progenitors into S and G2/M phases and increases the population of apoptotic cells in IL-7-cultured B cell progenitors. In addition, Manoalide reduced IL-7-induced phosphorylation of S6 compared to the control without inhibitor pre-treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Manoalide reverses venom preconditioning (VPC)-induced anti-inflammatory effects 24 h after surgical brain injury (SBI) in adult male Sprague-Dawley rats, 260 to 300 g[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

416.55

Formula

C₂₅H₃₆O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Manoalide
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HY-N7487
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