1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Mc-Dexamethasone

Mc-Dexamethasone is a agent-linker conjugate for ADC. Mc-Dexamethasone is made toxin Dexamethasone (HY-14648) conjugated to the non-cleavable MC linker. Dexamethasone is a glucocorticoid receptor agonist.

For research use only. We do not sell to patients.

Mc-Dexamethasone Chemical Structure

Mc-Dexamethasone Chemical Structure

CAS No. : 1618096-56-2

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Description

Mc-Dexamethasone is a agent-linker conjugate for ADC. Mc-Dexamethasone is made toxin Dexamethasone (HY-14648) conjugated to the non-cleavable MC linker. Dexamethasone is a glucocorticoid receptor agonist.

IC50 & Target[1]

Maytansinoids

 

Molecular Weight

543.63

Formula

C29H38FN3O6

CAS No.
SMILES

C[C@]([C@](O)1/C(CO)=N/NCCCN(C2=O)C(C=C2)=O)(C[C@@H]3O)[C@](C[C@H]1C)([H])[C@@](CCC4=CC5=O)([H])[C@]3([C@]4(C=C5)C)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (15.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8395 mL 9.1974 mL 18.3949 mL
5 mM 0.3679 mL 1.8395 mL 3.6790 mL
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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8395 mL 9.1974 mL 18.3949 mL 45.9872 mL
5 mM 0.3679 mL 1.8395 mL 3.6790 mL 9.1974 mL
10 mM 0.1839 mL 0.9197 mL 1.8395 mL 4.5987 mL
15 mM 0.1226 mL 0.6132 mL 1.2263 mL 3.0658 mL
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Mc-Dexamethasone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mc-Dexamethasone
Cat. No.:
HY-136290
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