MC-VC-PAB-MMAD

Cat. No.: HY-136316: FAQs
Data Sheet Handling Instructions

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MC-VC-PAB-MMAD is a agent-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker MC-VC-PAB.

For research use only. We do not sell to patients.

MC-VC-PAB-MMAD Chemical Structure

Size	Stock
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MC-VC-PAB-MMAD is a agent-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker MC-VC-PAB^[1].

IC₅₀ & Target

Auristatin

Molecular Weight

1368.72

Formula

C₇₁H₁₀₅N₁₁O₁₄S

SMILES

O=C(C[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@H]([C@@H](CC(N2[C@H]([C@@H]([C@H](C(N[C@@H](CC3=CC=CC=C3)C4=NC=CS4)=O)C)OC)CCC2)=O)OC)[C@@H](C)CC)=O)C(C)C)=O)=O)C=C1)=O)=O)CCCCCN5C(C=CC5=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9. [Content Brief]

MC-VC-PAB-MMAD Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-VC-PAB-MMADMicrotubule/TubulinDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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