2. Academic Validation
  3. Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

  • Bioorg Med Chem Lett. 1999 Oct 18;9(20):3057-60. doi: 10.1016/s0960-894x(99)00520-x.
M Ohyama 1,  T Tanaka,  T Ito,  M Iinuma,  K F Bastow,  K H Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.
PMID: 10571175 DOI: 10.1016/s0960-894x(99)00520-x
Abstract

Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.6, 0.7 and 2.0 microg/mL against KB, 1A9 and MCF-7 cells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also showed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1.6 microg/mL, respectively.

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