2. Academic Validation
  3. Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

  • Bioorg Med Chem Lett. 2003 Dec 15;13(24):4511-3. doi: 10.1016/j.bmcl.2003.08.028.
Christopher McGuigan 1,  Andrea Brancale,  Graciela Andrei,  Robert Snoeck,  Erik De Clercq,  Jan Balzarini
Affiliations

Affiliation

  • 1 Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK. [email protected]
PMID: 14643358 DOI: 10.1016/j.bmcl.2003.08.028
Abstract

Several novel bicyclic furanopyrimidine deoxy nucleosides have been designed, prepared and evaluated as anti-Varicella Zoster Virus agents. The compounds have long ether side chains. Uniquely amongst compounds of this family to date the present agents show dual anti- (VZV) and human cytomegalovirus (HCMV) activity. The lead compounds inhibit VZV at 10 nM and HCMV at 5 microM.

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