2. Academic Validation
  3. Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

  • Bioorg Med Chem Lett. 2006 Mar 1;16(5):1130-3. doi: 10.1016/j.bmcl.2005.11.095.
Raman K Bakshi 1,  Qingmei Hong,  Rui Tang,  Rubana N Kalyani,  Tanya Macneil,  David H Weinberg,  Lex H T Van der Ploeg,  Arthur A Patchett,  Ravi P Nargund
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. [email protected]
PMID: 16364639 DOI: 10.1016/j.bmcl.2005.11.095
Abstract

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.

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