2. Academic Validation
  3. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

  • Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7. doi: 10.1016/j.bmcl.2006.09.003.
Christa E Müller " href="affiliation-1" ref="linksrc=author_aff"> # 1,  Jamshed Iqbal,  Younis Baqi,  Herbert Zimmermann,  Anita Röllich,  Holger Stephan
Affiliations

Affiliation

  • 1 Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany. [email protected]
  • # Contributed equally.
PMID: 16997558 DOI: 10.1016/j.bmcl.2006.09.003
Abstract

Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K(6)H(2)[TiW(11)CoO(40)], exhibiting K(i) values of 0.140 microM (NTPDase1), 0.910 microM (NTPDase2), and 0.563 microM (NTPDase3). One of the compounds, (NH(4))(18)[NaSb(9)W(21)O(86)], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

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