2. Academic Validation
  3. Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia

Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia

  • J Nat Prod. 2007 Aug;70(8):1380-3. doi: 10.1021/np0701778.
Siew-Huah Lim 1,  Kooi-Mow Sim,  Zanariah Abdullah,  Osamu Hiraku,  Masahiko Hayashi,  Kanki Komiyama,  Toh-Seok Kam
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
PMID: 17608533 DOI: 10.1021/np0701778
Abstract

Four new Indole Alkaloids were obtained from two Kopsia species, 6-oxoleuconoxine (1) from the leaf extract of K. griffithii and kopsinitarine E (2), kopsijasminine (3), and kopsonoline (4) from the stem-bark extract of K. teoi. The structures of these Alkaloids were determined using NMR and MS analysis. Kopsijasminine (3) showed moderate activity in reversing multidrug resistance in vincristine-resistant KB cells.

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