2. Academic Validation
  3. Structure-activity relationship studies of small-molecule inhibitors of Wnt response

Structure-activity relationship studies of small-molecule inhibitors of Wnt response

  • Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7. doi: 10.1016/j.bmcl.2009.04.040.
Jianming Lu 1,  Zhiqiang Ma,  Jen-Chieh Hsieh,  Chih-Wei Fan,  Baozhi Chen,  Jamie C Longgood,  Noelle S Williams,  James F Amatruda,  Lawrence Lum,  Chuo Chen
Affiliations

Affiliation

  • 1 Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
PMID: 19410457 DOI: 10.1016/j.bmcl.2009.04.040
Abstract

Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-12238
    99.49%, Tankyrase Inhibitor