2. Academic Validation
  3. Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling

Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling

  • Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a007880. doi: 10.1101/cshperspect.a007880.
Bryan T MacDonald 1,  Xi He
Affiliations

Affiliation

  • 1 The F. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
PMID: 23209147 DOI: 10.1101/cshperspect.a007880
Abstract

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners Dishevelled and Axin, and finally to the inhibition of β-catenin phosphorylation and ensuing β-catenin stabilization.

Figures