1. Academic Validation
  2. Ginsenoside Rd Inhibits Glioblastoma Cell Proliferation by Up-Regulating the Expression of miR-144-5p

Ginsenoside Rd Inhibits Glioblastoma Cell Proliferation by Up-Regulating the Expression of miR-144-5p

  • Biol Pharm Bull. 2020;43(10):1534-1541. doi: 10.1248/bpb.b20-00338.
Guo-Min Liu 1 2 Tian-Cheng Lu 2 3 Mao-Lei Sun 2 4 Wen-Yuan Jia 1 2 Xuan Ji 2 4 Yun-Gang Luo 2 4
Affiliations

Affiliations

  • 1 Department of Orthopedics, the Second Hospital of Jilin University.
  • 2 Jilin Provincial Changbai Mountain Medicine Anti-Tumor Engineering Center, the Second Hospital of Jilin University.
  • 3 Life Sciences College, Jilin Agricultural University.
  • 4 Department of Stomatology, the Second Hospital of Jilin University.
Abstract

miR-144-5p exhibits anti-tumor activities in various cancers. Although treatment for glioblastoma has progressed rapidly, novel targets for glioblastoma are insufficient, particularly those used in precision medicine. In the current study, we found that ginsenoside Rd reduced the proliferation and migration of glioblastoma cells. Ginsenoside Rd up-regulated the tumor-suppressive miR-144-5p in glioblastoma cells. Moreover, Toll-like Receptor 2, which is a target of miR-144-5p, was down-regulated. After inhibition of miR-144-5p, the effect of Ginsenoside Rd on proliferation inhibition and down-regulation of Toll-like Receptor 2 was reduced. These data demonstrated the ginsenoside Rd/miR-144-5p/Toll-like Receptor 2 regulatory nexus that controls the glioblastoma pathogenesis of glioblastoma. Our work provided novel targets for glioblastoma diagnosis and treatment.

Keywords

Toll-like receptor 2; ginsenoside Rd; glioblastoma; miR-144-5p; proliferation.

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