2. Academic Validation
  3. Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study

Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study

  • Eur J Pharmacol. 2021 Sep 5;906:174232. doi: 10.1016/j.ejphar.2021.174232.
Xiaojian Huang 1,  Wenbin Pei 1,  Bowei Ni 1,  Rui Zhang 1,  Hongbo You 2
Affiliations

Affiliations

  • 1 Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
  • 2 Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address: [email protected].
PMID: 34090897 DOI: 10.1016/j.ejphar.2021.174232
Abstract

Osteoarthritis (OA) is a common degenerative joint disease blamed for pain and disability in the elderly. Galangin (GAL) is a natural flavonoid that exhibits anti-inflammatory properties in various inflammation diseases. However, the role of GAL in OA remains unclear. In this study, we investigate the role of GAL in the progress and development of OA in vitro and vivo. The results showed that IL-1β exposure resulted in increased expression of iNOS, COX-2, MMP1, MMP3, MMP13 and ADAMTS5 in rat chondrocytes. However, co-treatment with GAL significantly decreased theses inflammatory cytokines and catabolic factors expression. In addition, GAL reduced IL-1β-induced degradation of collagen II and aggrecan in chondrocytes. Furthermore, GAL significantly suppressed IL-1β-induced Akt phosphorylation and NF-κB activation in rat chondrocytes. In vivo, intra-articular injection of GAL could also reduce the cartilage degradation in the ACLT rat model. This study reveals galangin may act as a promising novel agent in the treatment of OA.

Keywords

Cartilage matrix; Galangin; Inflammation; NF-κB; Osteoarthritis.

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