2. Academic Validation
  3. Sulfite may disrupt estrogen homeostasis in human via inhibition of steroid arylsulfatase

Sulfite may disrupt estrogen homeostasis in human via inhibition of steroid arylsulfatase

  • Environ Sci Pollut Res Int. 2022 Mar;29(13):19913-19917. doi: 10.1007/s11356-021-18416-z.
Jun Zhang 1,  Shu-Shu Zhong 1,  Ke-Meng Zhao 1,  Ze-Hua Liu 2 3 4,  Zhi Dang 1,  Yu Liu 5
Affiliations

Affiliations

  • 1 School of Environment and Energy, South China University of Technology, Guangzhou, 510006, Guangdong, China.
  • 2 School of Environment and Energy, South China University of Technology, Guangzhou, 510006, Guangdong, China. [email protected].
  • 3 Key Lab Pollution Control & Ecosystem Restoration in Industry Cluster, Ministry of Education, Guangzhou, 510006, Guangdong, China. [email protected].
  • 4 Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling, Guangzhou, 510006, Guangdong, China. [email protected].
  • 5 School of Civil and Environmental Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
PMID: 35098465 DOI: 10.1007/s11356-021-18416-z
Abstract

Steroid arylsulfatase is an important Enzyme in human, which plays an important role in dynamic equilibrium of natural estrogens. On the other hand, sulfite can be endogenously produced as a consequence of human body's metabolism of sulfur-containing Amino acids, while its main sources to human are mainly derived from food as it is a widely used additive. Sulfite-sensitivity is a well-known phenomenon to a small proportion of populations. However, its potential adverse effects on healthy individuals have been hardly reported. It was for the first time reported in this study that sulfite could effectively inhibit arylsulfatase, and its IC50 values for the snail- and human urine-derived arylsulfatase were determined to be 71.9 and 142.8 µM, which were lower than the concentration of sulfite in some healthy population. Consequently, it appears that sulfite might disrupt estrogen homeostasis in human, and this deserves further investigation.

Keywords

Arylsulfatase; Disruption; Estrogen homeostasis; Inhibition; Sulfite.

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