2. Academic Validation
  3. A small molecule that reshapes the chromatin dynamics of FOXA1

A small molecule that reshapes the chromatin dynamics of FOXA1

  • Mol Cell. 2024 Nov 7;84(21):4049-4051. doi: 10.1016/j.molcel.2024.10.019.
Khadija Shahed Khan 1,  Billy Wai-Lung Ng 2
Affiliations

Affiliations

  • 1 School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
  • 2 School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: [email protected].
PMID: 39515290 DOI: 10.1016/j.molcel.2024.10.019
Abstract

In this issue, Won et al.1 report a covalent ligand binding the pioneer transcription factor FOXA1, altering its function and remodeling chromatin. This important finding highlights the potential of small molecules to modulate transcription factor activity and demonstrates the promise of chemical proteomics in discovering first-in-class ligands.

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