1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Medetomidine hydrochloride

Medetomidine hydrochloride  (Synonyms: MPV785)

Cat. No.: HY-17034B Purity: 99.92%
COA Handling Instructions

Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels.

For research use only. We do not sell to patients.

Medetomidine hydrochloride Chemical Structure

Medetomidine hydrochloride Chemical Structure

CAS No. : 86347-15-1

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10 mM * 1 mL in DMSO
ready for reconstitution
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10 mg USD 61 In-stock
50 mg USD 198 In-stock
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Description

Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels[1][2][3][4].

IC50 & Target[3]

α2-adrenergic receptor

1.08 nM (Ki)

α1-adrenergic receptor

1750 nM (Ki)

In Vitro

Medetomidine (0-1 µM, 1 h) hydrochloride inhibits aldosterone release from the adrenocortical cell suspension[7].
Medetomidine (10 nM) hydrochloride activates a kicking response in Cyprids[8].
Medetomidine (1 µM) hydrochloride increases cellular cAMP production by activating β-like receptors in CHO cells[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Medetomidine (200 μg/kg, p.o. or i.m.) hydrochloride induces a sedation in cats[4].
Medetomidine (20 µg/kg, i.v.) hydrochloride shows sedative and analgesic effects in dogs[5].
Medetomidine (0.05-0.3 mg/kg, s.c.) hydrochloride protects against Diazinon-induced toxicosis in mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diazinon (75 mg/kg, orally)-induced toxicosis in mice[6]
Dosage: 0.05, 0.1 and 0.3 mg/kg
Administration: Subcutaneous injection (s.c.), 15 min before Diazinon.
Result: Protected the mice from the toxicity induced by Diazinon.
Decreased the occurrence of Straub tail, excessive salivation and tremor.
Increased the latencies to onset of tremor and death when compared with control.
Animal Model: Dogs[5]
Dosage: 20 µg/kg
Administration: Intravenous injection (i.v.)
Result: Showed sedative and analgesic effects. Increased in SAP, MAP, DAP, MPAP, PCWP, CVP, SVR, PVR, core body temperature.
Decreased in HR, CO, CI, SV, SI, RR, pH.
Molecular Weight

236.74

Formula

C13H17ClN2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CN=CN1)C2=CC=CC(C)=C2C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (422.40 mM; Need ultrasonic)

Ethanol : 100 mg/mL (422.40 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (211.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2240 mL 21.1202 mL 42.2404 mL
5 mM 0.8448 mL 4.2240 mL 8.4481 mL
10 mM 0.4224 mL 2.1120 mL 4.2240 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Medetomidine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Medetomidine hydrochloride
Cat. No.:
HY-17034B
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