1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Meptazinol hydrochloride (Synonyms: IL-22811 hydrochloride; WY-22811 hydrochloride)

Cat. No.: HY-17467A
Handling Instructions

Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.

For research use only. We do not sell to patients.
Meptazinol hydrochloride Chemical Structure

Meptazinol hydrochloride Chemical Structure

CAS No. : 59263-76-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
10 mg USD 60 In-stock
50 mg USD 157 In-stock
100 mg USD 263 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic. IC50 Value: < 1 nM [1] Target: Opioid Receptor in vitro: Meptazinol inhibits a portion of 3H-labeled opiate and opioid peptide binding quite potently, with IC50 value under 1 nM [1]. in vivo: Given at equianalgesic doses, morphine (3.5 mg/kg i.v.) significantly lowers the pO2 over 20 mm Hg and raises the pCO2 over 10 mm Hg as measured in arterial blood samples, whereas meptazinol (10 mg/kg i.v.) has no significant effects on either [1]. The group receiving meptazinol demonstrated no cardiovascular changes although bispectral index dropped by an additional 19% when compared to 1 min after barbiturate injection [2]. Rapid and significant levels of MEP in plasma and CSF can be achieved after nasal administration whereas the oral administration resulted in considerably lower drug concentrations [3].

References
Molecular Weight

269.81

Formula

C₁₅H₂₄ClNO

CAS No.

59263-76-2

SMILES

OC1=CC=CC(C2(CC)CN(C)CCCC2)=C1.[H]Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Meptazinol hydrochloride
Cat. No.:
HY-17467A
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