1. Anti-infection
  2. Bacterial
  3. Metallo β-lactamase ligand 1

Metallo β-lactamase ligand 1 

Cat. No.: HY-136306
Handling Instructions

Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.

For research use only. We do not sell to patients.

Metallo β-lactamase ligand 1 Chemical Structure

Metallo β-lactamase ligand 1 Chemical Structure

CAS No. : 1087784-71-1

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Description

Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A[1].

In Vitro

One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent[1].
The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells[1].

In Vivo

After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate[1].

Molecular Weight

219.22

Formula

C₇H₉NO₅S

CAS No.

1087784-71-1

SMILES

CC1=C(S(=O)(N)=O)C(C(O)=O)=C(C)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Metallo β-lactamase ligand 1Bacterialβ-lactamaseantibioticsantibacterialsulfamoylcarboxylInhibitorinhibitorinhibit

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