2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Meldonium dihydrate

Meldonium dihydrate  (Synonyms: MET-88 dihydrate; Quaterin dihydrate)

Cat. No.: HY-B1836A Purity: ≥99.0%
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Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor.

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Meldonium dihydrate Chemical Structure

Meldonium dihydrate Chemical Structure

CAS No. : 86426-17-7

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Based on 2 publication(s) in Google Scholar

Other Forms of Meldonium dihydrate:

Meldonium dihydrate Related Antibodies

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Description

Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor[1][2].

IC50 & Target

IC50: 34-62 μM (human recombinant BBOX).
EC50: 21 μM (human OCTN2).
In Vitro

Meldonium (20-40 μM; 24 h) dihydrate ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meldonium dihydrate Related Antibodies

RT-PCR[3]

Cell Line: Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
Concentration: 20, or 40 μM
Incubation Time: 24 h
Result: Significantly decreased the mRNA expression of PFKP, PDK1, and PKM2 compared with the hypoxia group.

Western Blot Analysis[3]

Cell Line: Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
Concentration: 20, or 40 μM
Incubation Time: 24 h
Result: Significantly reduced the protein expression of PFKP, PKM2, and LDHA.
In Vivo

Meldonium (50, 100, or 200 mg/kg; once daily for 3 days) dihydrate modestly attenuates hypoxia-induced lung injury in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

182.22

Formula

C6H18N2O4
CAS No.
Appearance

Solid

SMILES

C[N+](C)(C)NCCC([O-])=O.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (548.79 mM; Need ultrasonic)

DMSO : 4.85 mg/mL (26.62 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4879 mL 27.4394 mL 54.8787 mL
5 mM 1.0976 mL 5.4879 mL 10.9757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.4879 mL 27.4394 mL 54.8787 mL 137.1968 mL
5 mM 1.0976 mL 5.4879 mL 10.9757 mL 27.4394 mL
10 mM 0.5488 mL 2.7439 mL 5.4879 mL 13.7197 mL
15 mM 0.3659 mL 1.8293 mL 3.6586 mL 9.1465 mL
20 mM 0.2744 mL 1.3720 mL 2.7439 mL 6.8598 mL
25 mM 0.2195 mL 1.0976 mL 2.1951 mL 5.4879 mL
H2O 30 mM 0.1829 mL 0.9146 mL 1.8293 mL 4.5732 mL
40 mM 0.1372 mL 0.6860 mL 1.3720 mL 3.4299 mL
50 mM 0.1098 mL 0.5488 mL 1.0976 mL 2.7439 mL
60 mM 0.0915 mL 0.4573 mL 0.9146 mL 2.2866 mL
80 mM 0.0686 mL 0.3430 mL 0.6860 mL 1.7150 mL
100 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.3720 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Meldonium dihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meldonium dihydrate86426-17-7MET-88 dihydrateQuaterin dihydrateMitochondrial MetabolismInhibitorinhibitorinhibit

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