2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. (-)-TK216

(-)-TK216 

Cat. No.: HY-122903A Purity: 99.45%
COA Handling Instructions

(-)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity.

For research use only. We do not sell to patients.

(-)-TK216 Chemical Structure

(-)-TK216 Chemical Structure

CAS No. : 1903783-78-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 210 In-stock
25 mg USD 440 In-stock
50 mg USD 770 In-stock
100 mg USD 1300 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (-)-TK216:

(-)-TK216 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(-)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity[1][2].

In Vitro

(-)-TK216 (compound 14; for 3 days) has an IC50<5 μM in SKES cells (Ewing Sarcoma cell line)[2].
(-)-TK216 has T1/2s of 27.7 mins, 2.8 mins, 23.1 mins and 40.8 mins for human, rat, mouse, dog liver microsomes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-TK216 Related Antibodies
In Vivo

(-)-TK216 (compound 14; 5 mg/kg for iv or 25 mg/kg for po) has T1/2s of 0.8 hours and 3.1 hours, and AUCs of 4131 h•(ng/mL) and 13152 h•(ng/mL) for iv and po, respectively, in BALB/c mice or Sprague Dawley rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

376.23

Appearance

Solid

Formula

C19H15Cl2NO3
CAS No.
SMILES

O=C1NC2=C(C(Cl)=CC=C2Cl)C1(CC(C3=CC=C(C4CC4)C=C3)=O)O.[Rotation (-)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (265.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6579 mL 13.2897 mL 26.5795 mL
5 mM 0.5316 mL 2.6579 mL 5.3159 mL
10 mM 0.2658 mL 1.3290 mL 2.6579 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.64 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.64 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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(-)-TK216 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(-)-TK2161903783-78-7DNA/RNA SynthesisSKESEwingSarcomaInhibitorinhibitorinhibit

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