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mitotane-d4

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13690S2
    Mitotane-d8

    2,4′-DDD-d8; o,p'-DDD-d8

    		 Apoptosis Cancer
    Mitotane-d8 is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
    <em>Mitotane-d8</em>

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