MK-6240 Precursor

Cat. No.: HY-126226 Purity: 98.24%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MK-6240 Precursor (6e) is the synthetic precursor of (18)F]-MK-6240. (18)F]-MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs.

For research use only. We do not sell to patients.

MK-6240 Precursor Chemical Structure

CAS No. : 1841444-11-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 278	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 278	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1600	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

505.52

Formula

C₂₆H₂₇N₅O₆

CAS No.

1841444-11-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OC(C)(C)C)N(C(OC(C)(C)C)=O)C1=C([N+]([O-])=O)C=CC2=C1C=C(N3C=CC4=C3C=NC=C4)N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (49.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9782 mL	9.8908 mL	19.7816 mL
5 mM	0.3956 mL	1.9782 mL	3.9563 mL
10 mM	0.1978 mL	0.9891 mL	1.9782 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.24%

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Data Sheet (276 KB) SDS (0 KB)

COA (258 KB) HNMR (263 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 May 26;59(10):4778-89. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9782 mL	9.8908 mL	19.7816 mL	49.4540 mL
	5 mM	0.3956 mL	1.9782 mL	3.9563 mL	9.8908 mL
	10 mM	0.1978 mL	0.9891 mL	1.9782 mL	4.9454 mL
	15 mM	0.1319 mL	0.6594 mL	1.3188 mL	3.2969 mL
	20 mM	0.0989 mL	0.4945 mL	0.9891 mL	2.4727 mL
	25 mM	0.0791 mL	0.3956 mL	0.7913 mL	1.9782 mL
	30 mM	0.0659 mL	0.3297 mL	0.6594 mL	1.6485 mL
	40 mM	0.0495 mL	0.2473 mL	0.4945 mL	1.2364 mL