1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML67-33

ML67-33 

Cat. No.: HY-120348 Purity: >98.0%
Handling Instructions

ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively.

For research use only. We do not sell to patients.

ML67-33 Chemical Structure

ML67-33 Chemical Structure

CAS No. : 1443290-89-8

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Description

ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].

IC50 & Target

EC50: 36.3 μM (K2P2.1 (TREK-1)), 9.7 μM (K2P2.1 (TREK-1), in HEK293 cells)[1].

In Vitro

ML67-33 activates K2P channels and mutants with EC50s of 21.8±1.3 μM, 49.4±1.1 μM, 30.2±1.4 μM, and 27.3±1.2 μM for K2P2.1 (TREK-1) W275S, K2P2.1 (TREK-1)-3G, K2P10.1 (TREK-2), K2P4.1 (TRAAK), respectively[1].

Molecular Weight

374.27

Formula

C₁₈H₁₇Cl₂N₅

CAS No.

1443290-89-8

SMILES

CC1(C)C2=C(C=CC(Cl)=C2)N(CCC3=NN=NN3)C4=CC=C(Cl)C=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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ML67-33
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