1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. Mutabilol

Mutabilol 

Cat. No.: HY-N10562
Handling Instructions

Mutabilol (compound 1) is a potent p-glycoprotein (P-gp) regulator. Mutabilol is a nature product could be isolated from Plectranthus mutabilis leaves. Mutabilol increases the P-gp expression in NCI-H460/R cells.

For research use only. We do not sell to patients.

Mutabilol Chemical Structure

Mutabilol Chemical Structure

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Description

Mutabilol (compound 1) is a potent p-glycoprotein (P-gp) regulator. Mutabilol is a nature product could be isolated from Plectranthus mutabilis leaves. Mutabilol increases the P-gp expression in NCI-H460/R cells[1].

In Vitro

Mutabilol (compound 1; 2, 5, 10, 20, and 50 μM; 72 h) has low toxicity with IC50 values of >50, >50, and >50 μM for NCI-H460, NCI-H460/R, and MRC-5 cells, respectively[1].
Mutabilol (5 and 10 μM; 72 h) stimulates P-gp activity by a direct interaction and decreases the Rho123 accumulation in NCI-H460/R cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NCI-H460, NCI-H460/R, and MRC-5 cells
Concentration: 2, 5, 10, 20, and 50 μM
Incubation Time: 72 hours
Result: Showed low toxicity of cancer cell lines (IC50>50μM)
Molecular Weight

332.39

Formula

C19H24O5

SMILES

O[[email protected]@]12C(C(C(C3=C2C(O)=C(C(C(C)C)=C3)O)=O)=O)C(C)(C)CCC1

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Mutabilol
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HY-N10562
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