1. Anti-infection
  2. Antibiotic
  3. Mycalolide B

Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+.

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Mycalolide B Chemical Structure

Mycalolide B Chemical Structure

CAS No. : 122752-21-0

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Description

Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].

IC50 & Target

actomyosin ATPase[1]

In Vitro

Mycalolide-B belongs to macrolide antibiotics and consists of tris-oxazole with strong cytotoxic activity (IC50: 10-50 nM for growth of L1210 murine leukemia cells). Mycalolide-B, a toxin isolated from marine sponge, inhibits smooth muscle contractions without changing cytosolic Ca2+ levels. Mycalolide-B also inhibits Ca2+-induced contraction in permeabilized smooth muscles. Mycalolide-B inhibits superprecipitation and Mg2+-ATPase activity stimulated by Ca2+ without changing myosin light chain phosphorylation. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1027.16

Formula

C52H74N4O17

CAS No.
SMILES

CO[C@@H]1C2=COC(C3=COC(C4=COC(/C=C/C[C@@H]([C@H]([C@@H](OC(C[C@H](C/C=C/C([C@@H]1C)=O)O)=O)C[C@H](OC)[C@@H](C)CC[C@@H](OC([C@H](OC)COC)=O)[C@H](C)[C@H](OC(C)=O)[C@H](C)/C=C/N(C)C=O)C)OC)=N4)=N3)=N2

Structure Classification
Initial Source

marine sponge

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Mycalolide B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mycalolide B
Cat. No.:
HY-N8493
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