1. Apoptosis
  2. c-Myc
  3. MYCi975

MYCi975 (Synonyms: NUCC-0200975)

Cat. No.: HY-129601
Handling Instructions

MYCi975 (NUCC-0200975) is an orally active MYC inhibitor, which disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 (NUCC-0200975) exhibits potent anti-tumor efficacy with good tolerability, increases tumor immune cell infiltration, and sensitizes tumors to anti-PD1 immunotherapy.

For research use only. We do not sell to patients.

MYCi975 Chemical Structure

MYCi975 Chemical Structure

CAS No. : 2289691-01-4

Size Price Stock
10 mM * 1 mL in DMSO USD 432 Ask For Quote & Lead Time
5 mg USD 350 Ask For Quote & Lead Time
10 mg USD 570 Ask For Quote & Lead Time
25 mg USD 990 Ask For Quote & Lead Time
50 mg USD 1650 Ask For Quote & Lead Time
100 mg USD 2250 Ask For Quote & Lead Time

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Description

MYCi975 (NUCC-0200975) is an orally active MYC inhibitor, which disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 (NUCC-0200975) exhibits potent anti-tumor efficacy with good tolerability, increases tumor immune cell infiltration, and sensitizes tumors to anti-PD1 immunotherapy[1].

IC50 & Target

MYC[1]

In Vitro

MYCi975 (3 days) inhibits P493-6, MV411, and SK-N-B2 cells viability in an MYC-dependent manner with IC50s of 3.7, 3.9, 6.4 μM, respectively[1].

In Vivo

MYCi975 exhibits excellent pharmacokinetic profiles following p.o., i.p., or i.v. administration. The half-lives observed are 7 and 12 hours when dosed at 100 and 250 mg/kg p.o., respectively. The Cmax values attained are 41,533 ng/mL (74 μM) and 54,000 ng/mL (96 μM), respectively[1].
MYCi975 significantly inhibits tumor growth and increases survival in the MycCaP allograft model with animals tolerating a 100 mg/kg/day i.p. dosing for 14 days[1].

Molecular Weight

561.30

Formula

C₂₅H₁₆Cl₂F₆N₂O₂

CAS No.

2289691-01-4

SMILES

OC1=C(C2=CC(C(F)(F)F)=NN2C)C=CC(OCC3=CC=C(Cl)C=C3)=C1C4=CC=C(Cl)C(C(F)(F)F)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MYCi975NUCC-0200975MYCi 975MYCi-975NUCC0200975NUCC 0200975c-MycMycInhibitorinhibitorinhibit

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