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MYLS22 

Cat. No.: HY-136446
Handling Instructions

MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor. MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression.

For research use only. We do not sell to patients.

MYLS22 Chemical Structure

MYLS22 Chemical Structure

CAS No. : 306959-01-3

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Description

MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor. MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression[1].

IC50 & Target

OPA1[1]

In Vivo

MYLS22 (10 mg/kg/die; peritumoral injection; every 2 days for 14 days) causes the tumor growth curtailed mice[1].

Animal Model: 6-week-old C57BL6/J mice with B16F10 melanomas[1]
Dosage: 10 mg/kg/die
Administration: Peritumoral injection; every 2 days for 14 days
Result: Caused the tumor growth curtailed.
Molecular Weight

443.52

Formula

C₂₄H₂₁N₅O₂S

CAS No.

306959-01-3

SMILES

O=C(C(S1)=CC2=C1N(C3=CC=CC=C3)N=C2C)NC4=C(C)N(C)N(C5=CC=CC=C5)C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (187.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2547 mL 11.2734 mL 22.5469 mL
5 mM 0.4509 mL 2.2547 mL 4.5094 mL
10 mM 0.2255 mL 1.1273 mL 2.2547 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MYLS22MYLS 22MYLS-22Othersfirst-in-classopticatrophy1OPA1endothelialtumorInhibitorinhibitorinhibit

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