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(SU11662; SU 11662; SU-11662)
N-Desethyl Sunitinib Chemical Structure
|Product name: N-Desethyl Sunitinib|
|Cat. No.: HY-10873|
N-desethyl sunitinib(SU-11662) is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).
Targe: VEGFR; PDGFRβ
N-Desethyl Sunitinib is a major and pharmacologically active metabolite of the tyrosine kinase inhibitor and anticancer drug Sunitinib. Sunitinib also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib exhibits antiangiogenic and antitumor activity in multiple xenograft models.
|M.Wt||370.42||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||2.6996 mL||13.4982 mL||26.9964 mL|
|5 mM||0.5399 mL||2.6996 mL||5.3993 mL|
|10 mM||0.2700 mL||1.3498 mL||2.6996 mL|
. Tang, Seng Chuan; Lankheet, Nienke A. G.; Poller, Birk et al. P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. Journal of Pharmacology and Experimental Therapeutics (2012), 341(1), 164-173.
. Penot P, Bouaziz JD, Battistella M, Kerob D, Pagès C, Vilmer C, Basset-Seguin N, Madjessli N, Comte C, Farges C, Bagot M, le Maignan C, Lebbé C.Multiple metastatic epithelioid sarcoma stabilization under sunitinib malate treatment.Br J Dermatol. 2012 Sep 10.
. Nowak AK, Millward MJ, Creaney J, Francis RJ, Dick IM, Hasani A, van der Schaaf A, Segal A, Musk AW, Byrne MJ.A Phase II Study of Intermittent Sunitinib Malate as Second-Line Therapy in Progressive Malignant Pleural Mesothelioma.J Thorac Oncol. 2012 Sep;7(9):1449-56.
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