2. Immunology/Inflammation
  3. Interleukin Related
  4. Nadunolimab

Nadunolimab is a human monoclonal IgG1 antibody targeting IL1RAP. Nadunolimab blocks IL-1α and IL-1β signaling and triggering antibody-dependent cellular cytotoxicity. Nadunolimab can be used in research of cancer.

For research use only. We do not sell to patients.

Nadunolimab Chemical Structure

Nadunolimab Chemical Structure

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Based on 1 publication(s) in Google Scholar

Nadunolimab Related Antibodies

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Description

Nadunolimab is a human monoclonal IgG1 antibody targeting IL1RAP. Nadunolimab blocks IL-1α and IL-1β signaling and triggering antibody-dependent cellular cytotoxicity. Nadunolimab can be used in research of cancer[1].

IC50 & Target

IL-1α

 

IL-1β

 

In Vitro

Nadunolimab (20 µg/mL; 30 min and 1 h; A549 cells and BxPC3 cells) reduces IL-1α-induced release of pro-infamma tory cytokines and chemokines, including IL-1β, IL-6 TNF-α and MIP-1α, and CXCL1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nadunolimab Related Antibodies
In Vivo

Nadunolimab (10 mg/kg; i.p.; twice on day 1 and thereafter twice weekly; nude BALB/c mice with LU2503 or MC38 tumors) improves the anti‑tumor efficacy of chemotherapy and blocks both murine IL-1α and IL-1β signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude BALB/c mice with LU2503 or MC38 tumors[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; twice on day 1 and thereafter twice weekly
Result: Reduced tumor volume in combination with Cisplatin (HY-17394) and Gemcitabine (HY-17026).
Blocked both murine IL-1α and IL-1β signaling.
Clinical Trial
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Nadunolimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.11%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Nadunolimab Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NadunolimabInterleukin RelatedILIgG1 antibodyhumanized monoclonal antibodyantibody-dependent cellular cytotoxicityanticancerA549 cellsBxPC3 cellsCisplatinGemcitabineInhibitorinhibitorinhibit

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