1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Nivolumab (anti-PD-1)

Nivolumab (anti-PD-1) 

Cat. No.: HY-P9903A Purity: 99.20%

Nivolumab (anti-PD-1) is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer.

For research use only. We do not sell to patients.

Nivolumab (anti-PD-1) Chemical Structure

Nivolumab (anti-PD-1) Chemical Structure

CAS No. : 946414-94-4

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1 mg USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
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Based on 6 publication(s) in Google Scholar

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Description

Nivolumab (anti-PD-1) is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer[1].

In Vitro

Nivolumab (anti-PD-1) binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab (anti-PD-1) binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab (anti-PD-1) also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (anti-PD-1) (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nivolumab (anti-PD-1) (10 and 50 mg/kg, i.v.) is well tolerated in cynomolgus monkeys. Serum chemistry changes are limited to a reversible 28% decrease in T3 at week 13 in females treated with 50 mg/kg. T4 and TSH levels are unchanged. In males treated with 50 mg/kg, there are no changes in T3, T4, or TSH levels. Nivolumab (anti-PD-1) exposure increases in an approximately dose-proportional manner between 10 and 50 mg/kg, with no substantial sex differences noted[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
SMILES

[Nivolumab (anti-PD-1)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

Purity: 99.20%

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Nivolumab (anti-PD-1)
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