1. Metabolic Enzyme/Protease
    Neuronal Signaling
    GPCR/G Protein
    Autophagy
  2. Endogenous Metabolite
    Adrenergic Receptor
    Autophagy
  3. Noradrenaline tartrate

Noradrenaline tartrate (Synonyms: Levarterenol tartrate; L-Noradrenaline tartrate)

Cat. No.: HY-13715C
Handling Instructions

Norepinephrine tartrate (Levarterenol tartrate), a naturally occurring chemical in the body that acts as both a stress hormone and neurotransmitter, is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

For research use only. We do not sell to patients.

Noradrenaline tartrate Chemical Structure

Noradrenaline tartrate Chemical Structure

CAS No. : 51-40-1

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Top Publications Citing Use of Products

    Noradrenaline tartrate purchased from MCE. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311.

    Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

    Noradrenaline tartrate purchased from MCE. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.
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    Description

    Norepinephrine tartrate (Levarterenol tartrate), a naturally occurring chemical in the body that acts as both a stress hormone and neurotransmitter, is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

    IC50 & Target

    EC50: 5.37 μM (β1-selective adrenergic receptor)[1].

    In Vitro

    Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine (NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1].
    Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment[2].
    Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
    Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2].

    RT-PCR[2]

    Cell Line: Subcutaneous preadipocytes Adipocytes.
    Concentration: 10 μM.
    Incubation Time: 6 hours.
    Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA)
    Molecular Weight

    319.26

    Formula

    C₁₂H₁₇NO₉

    CAS No.

    51-40-1

    SMILES

    OC1=CC=C([[email protected]@H](O)CN)C=C1O.OC([[email protected]](O)[[email protected]@H](O)C(O)=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    NoradrenalineLevarterenolL-NoradrenalineEndogenous MetaboliteAdrenergic ReceptorAutophagyBeta ReceptorInhibitorinhibitorinhibit

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