1. Neuronal Signaling
    Stem Cell/Wnt
  2. Notch
  3. CB-103

CB-103 

Cat. No.: HY-135145 Purity: 99.77%
Handling Instructions

CB-103 is a first-in-class orally active notch signaling pathway inhibitor extracted from patent US9296682B2. CB-103 has anti-tumor activity.

For research use only. We do not sell to patients.

CB-103 Chemical Structure

CB-103 Chemical Structure

CAS No. : 218457-67-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 70 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

CB-103 is a first-in-class orally active notch signaling pathway inhibitor extracted from patent US9296682B2. CB-103 has anti-tumor activity[1][2][3].

IC50 & Target

notch signaling pathway[1]

In Vitro

CB-103 acts as a Pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex[2].
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines[2].
CB-103 exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines[2].

Cell Viability Assay[1]

Cell Line: RPMI 8402, KOPTK1, PANC1, nRas driven melanoma cells
Concentration: 10 μM
Incubation Time: 4 days, 6 days
Result: Caused a significant reduction in their growth potential.
In Vivo

CB-103 inhibits NOTCH dependent cellular processes in mice[2].
CB-103 blocks in vivo growth of PDX models of T-ALL[2].
CB-103 (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer[3].
CB-103 exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors[3].

Animal Model: NSG mice, triple negative breast cancer mouse xenograft model[3]
Dosage: 25 mg/kg
Administration: Oral administration/Intraperitoneal injection; 2x daily; for 2 weeks
Result: Inhibited growth of GSI/Mab resistant triple negative breast cancer.
Clinical Trial
Molecular Weight

242.32

Formula

C₁₅H₁₈N₂O

CAS No.

218457-67-1

SMILES

NC1=CC=C(OC2=CC=C(C(C)(C)C)C=C2)N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1031.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1268 mL 20.6339 mL 41.2677 mL
5 mM 0.8254 mL 4.1268 mL 8.2535 mL
10 mM 0.4127 mL 2.0634 mL 4.1268 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.77%

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Keywords:

CB-103CB103CB 103NotchnotchsignalingpathwayleukemiaInhibitorinhibitorinhibit

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Product Name:
CB-103
Cat. No.:
HY-135145
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