2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. NTP42

NTP42 

Cat. No.: HY-129851 Purity: 98.02%
COA Handling Instructions

NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46619. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH).

For research use only. We do not sell to patients.

NTP42 Chemical Structure

NTP42 Chemical Structure

CAS No. : 2055599-51-2

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Solution
10 mM * 1 mL in DMSO USD 198 In-stock
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10 mM * 1 mL
ready for reconstitution
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50 mg USD 825 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46619[1]. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH)[2].

IC50 & Target[1]

TXA2

 

In Vivo

NTP42 (0.25 mg/kg BID) is potent in a monocrotaline (MCT)-induced PAH rat model (28-day drug treatment is initiated within 24 h post-MCT) in haemodynamic assessments. NTP42 reduces the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP). Moreover, NTP42 is superior to Sildenafil and Selexipag in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar-Kyoto rats[2]
Dosage: 0.25 mg/kg BID
Administration: 28-day drug treatment was initiated within 24 h post-MCT (60 mg/kg)
Result: Reduced the MCT-induced PAH, including mPAP and RSVP.
Clinical Trial
Molecular Weight

515.53

Appearance

Solid

Formula

C25H23F2N3O5S
CAS No.
SMILES

O=S(C1=CC(C#N)=CC=C1OC2=CC(C3=CC=C(OC(F)F)C=C3)=CC=C2)(NC(NC(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (60.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9398 mL 9.6988 mL 19.3975 mL
5 mM 0.3880 mL 1.9398 mL 3.8795 mL
10 mM 0.1940 mL 0.9699 mL 1.9398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

NTP422055599-51-2NTP 42NTP-42Prostaglandin ReceptorthromboxaneTXA2pulmonaryarterialhypertensionPAHInhibitorinhibitorinhibit

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