1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. NTP42

NTP42 

Cat. No.: HY-129851 Purity: 98.43%
Handling Instructions

NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46609. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH).

For research use only. We do not sell to patients.

NTP42 Chemical Structure

NTP42 Chemical Structure

CAS No. : 2055599-51-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 397 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46609[1]. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH)[2].

IC50 & Target[1]

TXA2

 

In Vivo

NTP42 (0.25 mg/kg BID) is potent in a monocrotaline (MCT)-induced PAH rat model (28-day drug treatment is initiated within 24 h post-MCT) in haemodynamic assessments. NTP42 reduces the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP). Moreover, NTP42 is superior to Sildenafil and Selexipag in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals[2].

Animal Model: Male Wistar-Kyoto rats[2]
Dosage: 0.25 mg/kg BID
Administration: 28-day drug treatment was initiated within 24 h post-MCT (60 mg/kg)
Result: Reduced the MCT-induced PAH, including mPAP and RSVP.
Molecular Weight

515.53

Formula

C₂₅H₂₃F₂N₃O₅S

CAS No.

2055599-51-2

SMILES

O=S(C1=CC(C#N)=CC=C1OC2=CC(C3=CC=C(OC(F)F)C=C3)=CC=C2)(NC(NC(C)(C)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (60.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9398 mL 9.6988 mL 19.3975 mL
5 mM 0.3880 mL 1.9398 mL 3.8795 mL
10 mM 0.1940 mL 0.9699 mL 1.9398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NTP42NTP 42NTP-42Prostaglandin ReceptorthromboxaneTXA2pulmonaryarterialhypertensionPAHInhibitorinhibitorinhibit

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Product name:
NTP42
Cat. No.:
HY-129851
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