1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. NU1025

NU1025 

製品番号: HY-15044 純度: >98.0%
取扱説明書

NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity.

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NU1025 構造式

NU1025 構造式

CAS 番号 : 90417-38-2

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 132 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 120 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 400 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 650 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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製品説明

NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity[1][2][3].

IC50 & Target

IC50: 400 nM (PARP)[2]
Ki: 48 nM (PARP)[3]

体外実験

NU1025 (0.2 mM) pretreatment restores cell viability to approximately 73% and 82% in H2O2 and SIN-1 injured cells, respectively[1].
NU1025 enhances the cytotoxicity of the DNA-methylating agent MTIC, γ-irradiation and bleomycin 3.5-, 1.4- and 2-fold respectively in L1210 cells. The recovery from potentially lethal γ-irradiation damage cytotoxicity in plateau-phase cells is also inhibited by NU 1025. NU1025 causes a marked retardation of DNA repair[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 0.2 mM
Incubation Time: 6.5 hours
Result: Restored cell viability to approximately 73% and 82% in H2O2 and SIN-1 injured cells.
体内実験

NU1025 (1-3 mg/kg; intraperitoneal injection; male Sprague Dawley rats) treatment at 1 and 3 mg/kg reduces total infarct volume to 25% and 45%, respectively, when administered 1 h before reperfusion. NU1025 also produces significant improvement in neurological deficits. Neuroprotection with NU1025 is associated with reduction in PAR accumulation, reversal of brain NAD depletion and reduction in DNA fragmentation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (250-270 g) induced focal cerebral ischemia[1]
Dosage: 1 mg/kg, 3 mg/kg
Administration: Intraperitoneal injection
Result: At 1 and 3 mg/kg, reduced total infarct volume to 25% and 45%, respectively.
分子量

176.17

分子式

C₉H₈N₂O₂

CAS 番号

90417-38-2

SMILES

OC1=C(N=C(C)NC2=O)C2=CC=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (709.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6763 mL 28.3817 mL 56.7634 mL
5 mM 1.1353 mL 5.6763 mL 11.3527 mL
10 mM 0.5676 mL 2.8382 mL 5.6763 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (11.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (11.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
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Keywords:

NU1025NU 1025NU-1025PARPpoly ADP ribose polymeraseNeuroprotectivecytotoxicityanti-cancerDNArepairNADPARInhibitorinhibitorinhibit

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製品名:
NU1025
製品番号:
HY-15044
数量:
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