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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

NVP-AUY922

HY-10215

(Luminespib; AUY922; VER-52296; NVP-AUY 922; AUY-922; VER 52296; VER52296)

NVP-AUY922

NVP-AUY922 Chemical Structure

AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1.

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Free sample   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
10 mg $70 In-stock
25 mg $140 In-stock
100 mg $350 In-stock
200 mg $600 In-stock
500 mg $1100 In-stock
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5 g Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €75 In-stock
10 mg €69 In-stock
25 mg €137 In-stock
100 mg €343 In-stock
200 mg €588 In-stock
500 mg €1078 In-stock
1 g Get quote
5 g Get quote

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Product name: NVP-AUY922
Cat. No.: HY-10215

NVP-AUY922 Data Sheet

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    Purity: 98.87%

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Biological Activity of NVP-AUY922

AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1.
IC50 Value: 13 nM(HSP90α); 21 nM(HSP90β)
Target: HSP90
in vitro: NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex.
in vivo: Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 465.54 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C26H31N3O5
CAS No 747412-49-3
Solvent & Solubility

DMSO: ≥ 62 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1480 mL 10.7402 mL 21.4804 mL
5 mM 0.4296 mL 2.1480 mL 4.2961 mL
10 mM 0.2148 mL 1.0740 mL 2.1480 mL

References on NVP-AUY922

Inhibitor Kit

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