2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38α inhibitor 2

p38α inhibitor 2 

Cat. No.: HY-131335 Purity: 98.03%
COA Handling Instructions

p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets.

For research use only. We do not sell to patients.

p38α inhibitor 2 Chemical Structure

p38α inhibitor 2 Chemical Structure

CAS No. : 1095003-80-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 366 In-stock
Solution
10 mM * 1 mL in DMSO USD 366 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 580 In-stock
25 mg USD 1100 In-stock
50 mg USD 1700 In-stock
100 mg USD 2500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

p38α inhibitor 2 Related Antibodies

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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  • Purity & Documentation

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  • Customer Review

Description

p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1].

IC50 & Target[1]

p38α MAPK

9.6 (pIC50)

Molecular Weight

475.58

Appearance

Solid

Formula

C27H33N5O3
CAS No.
SMILES

O=C(NC1CC1)C2=CC=C(C)C(N3C(C(NC(C4=CC=CC=C4OCCNC)(C)C)=NC=C3)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (525.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1027 mL 10.5135 mL 21.0270 mL
5 mM 0.4205 mL 2.1027 mL 4.2054 mL
10 mM 0.2103 mL 1.0513 mL 2.1027 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 6.25 mg/mL (13.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 6.25 mg/mL (13.14 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 6.25 mg/mL (13.14 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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p38α inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

p38α inhibitor 21095003-80-7p38 MAPKselectivechannelPBMCinflammationkinasesInhibitorinhibitorinhibit

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