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Perivine (Synonyms: Perivin)

Cat. No.: HY-N6062
Handling Instructions

Perivine (Perivin) targets protein retinoblastoma-associated proteins (RbAp48) and resolves the instability of the RbAp48-FOG-1 complex. Perivine can be used for the study of Alzheimer's disease.

For research use only. We do not sell to patients.

Perivine Chemical Structure

Perivine Chemical Structure

CAS No. : 2673-40-7

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Description

Perivine (Perivin) targets protein retinoblastoma-associated proteins (RbAp48) and resolves the instability of the RbAp48-FOG-1 complex. Perivine can be used for the study of Alzheimer's disease[1].

IC50 & Target

IC50: Retinoblastoma-associated proteins (RbAp48)[1]

In Vitro

Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48.
Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy[1].

Molecular Weight

338.40

Formula

C₂₀H₂₂N₂O₃

CAS No.

2673-40-7

SMILES

O=C([[email protected]]([[email protected]@H](NC/1)CC(C2=CC=CC=C2N3)=C3C4=O)[[email protected]@H](C4)C1=C/C)OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PerivinePerivinOthersAlzheimer's diseaseADmemory lossRbAp48Inhibitorinhibitorinhibit

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