2. Metabolic Enzyme/Protease
  3. MMP
  4. PF-00356231 hydrochloride

PF-00356231 hydrochloride 

Cat. No.: HY-114091 Purity: 99.52%
COA Handling Instructions

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.

For research use only. We do not sell to patients.

PF-00356231 hydrochloride Chemical Structure

PF-00356231 hydrochloride Chemical Structure

CAS No. : 820223-77-6

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5 mg USD 400 In-stock
10 mg USD 640 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PF-00356231 hydrochloride

View All MMP Isoform Specific Products:

View All Isoforms
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].

IC50 & Target[1]

MMP-12

1.4 μM (IC50)

MMP13

0.65 nM (IC50)

MMP-3

0.39 μM (IC50)

MMP-8

1.7 μM (IC50)

MMP-9

0.98 μM (IC50)

In Vitro

PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

464.96

Appearance

Solid

Formula

C25H21ClN2O3S
CAS No.
SMILES

OC(C[[email protected]](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1507 mL 10.7536 mL 21.5072 mL
5 mM 0.4301 mL 2.1507 mL 4.3014 mL
10 mM 0.2151 mL 1.0754 mL 2.1507 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.52%

COA (250 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PF-00356231820223-77-6PF00356231PF 00356231MMPMatrix metalloproteinasesspecificnon-peptidicnon-zincchelatingligandcomplexS1pocketInhibitorinhibitorinhibit

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