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Products are for research use only. Not for human use. We do not sell to patients.
(PF 04620110; PF04620110)
PF-04620110 Chemical Structure
|Product name: PF-04620110|
|Cat. No.: HY-13009|
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
IC50 value: 19 nM 
PF-04620110 and imipramine (internal standard) were separated using a Hypersil Gold C18 column, with a mixture of acetonitrile and 10 mm ammonium formate (90:10, v/v) as the mobile phase. The ion transitions monitored in positive-ion mode [M + H](+) of multiple-reaction monitoring were m/z 397.0 → 260.2 for PF-04620110 and m/z 280.8 → 86.0 for imipramine. The detector response was specific and linear for PF-04620110 at concentrations within the range 0.05-50 μg/mL and the signal-to-noise ratios for the samples were ≥10 .
|M.Wt||396.44||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
in DMSO > 10 mM
|1 mg||5 mg||10 mg|
|1 mM||2.5224 mL||12.6122 mL||25.2245 mL|
|5 mM||0.5045 mL||2.5224 mL||5.0449 mL|
|10 mM||0.2522 mL||1.2612 mL||2.5224 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|PF-04620110||Pfizer Inc||Non-insulin dependent diabetes||31-JUL-10||31-AUG-10||Phase 1||13-SEP-13|
|Pfizer Inc||Obesity||31-JUL-10||31-AUG-10||Phase 1||13-SEP-13|
|Pfizer Inc||Obesity||30-JUN-10||01-JAN-11||Phase 1||14-SEP-13|
|Pfizer Inc||Non-insulin dependent diabetes||30-JUN-10||01-JAN-11||Phase 1||14-SEP-13|
|Pfizer Inc||Obesity||30-JUN-11||31-AUG-11||Phase 1||14-SEP-13|
|Pfizer Inc||Non-insulin dependent diabetes||28-FEB-11||01-MAY-11||Phase 1||14-SEP-13|
. Lee KR, et al. Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies. Biomed Chromatogr. 2013 Jul;27(7):846-52.
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