1. Cell Cycle/DNA Damage
  2. CDK
  3. PF-07104091

PF-07104091 

Cat. No.: HY-137894
Handling Instructions

PF-07104091 is a selective CDK2 inhibitor, with a Ki of 1.16 nM for CDK2/cyclin E1. PF-07104091 has anti-tumor activity for cyclinE-amplified cancers.

For research use only. We do not sell to patients.

PF-07104091 Chemical Structure

PF-07104091 Chemical Structure

CAS No. : 2460249-19-6

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Description

PF-07104091 is a selective CDK2 inhibitor, with a Ki of 1.16 nM for CDK2/cyclin E1. PF-07104091 has anti-tumor activity for cyclinE-amplified cancers[1].

IC50 & Target[1]

CDK2/cyclin E1

1.16 nM (Ki)

In Vitro

PF-07104091 (Example 13) is a CDK2-selective inhibitor, with 100-fold selectivity against CDK1, 200 to 400-fold selectivity against CDK4 and CDK6, 170-fold selectivity against CDK9, and greater than 500-fold selectivity against GSK3B[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

404.46

Formula

C₁₉H₂₈N₆O₄

CAS No.
SMILES

O=C(C1=CC(COC)=NN1C)NC2=NNC([[email protected]](CC3)([H])C[[email protected]@H]3OC(NC(C)C)=O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PF-07104091PF07104091PF 07104091CDKCyclin dependent kinasemetastaticsmallcelllungcancerovariancyclinEInhibitorinhibitorinhibit

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PF-07104091
Cat. No.:
HY-137894
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