1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Phentolamine mesylate

Phentolamine mesylate (Synonyms: Phentolamine methanesulfonate)

製品番号: HY-B0362A 純度: 99.90%
取扱説明書

Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction.

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Phentolamine mesylate 構造式

Phentolamine mesylate 構造式

CAS 番号 : 65-28-1

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
Solution
10 mM * 1 mL in Water USD 73 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 在庫あり
Estimated Time of Arrival: December 31
Solid
100 mg USD 66 在庫あり
Estimated Time of Arrival: December 31
500 mg USD 198 在庫あり
Estimated Time of Arrival: December 31
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].

IC50 & Target

α-adrenergic[1]

体外実験

Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively[3].
Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively[4].
Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) significantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner[4].
Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験
分子量

377.46

分子式

C18H23N3O4S

CAS 番号
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度
体外: 

H2O : ≥ 50 mg/mL (132.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6493 mL 13.2464 mL 26.4929 mL
5 mM 0.5299 mL 2.6493 mL 5.2986 mL
10 mM 0.2649 mL 1.3246 mL 2.6493 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (264.93 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution

*All of the co-solvents are available by MCE.
参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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製品名:
Phentolamine mesylate
製品番号:
HY-B0362A
数量:
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