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  3. PI3Kγ inhibitor 4

PI3Kγ inhibitor 4 

Cat. No.: HY-132299
Handling Instructions

PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation.

For research use only. We do not sell to patients.

PI3Kγ inhibitor 4 Chemical Structure

PI3Kγ inhibitor 4 Chemical Structure

CAS No. : 1821038-80-5

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Description

PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation[1].

IC50 & Target[1]

PI3Kγ

40 nM (IC50)

PI3Kα

300 nM (IC50)

In Vitro

PI3Kγ inhibitor 4 inhibits PI3Kγ and PI3Kα in U937 cells, with IC50s of 120 nM and 6250 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PI3Kγ inhibitor 4 (10-20 mg/kg; a single p.o.) dose dependently inhibits the amplitude of the enhanced pause (ΔPenh) response to ovalbumin in a model of airway inflammation[1].
PI3Kγ inhibitor 4 (a single p.o.) exhibits high oral bioavailability (72, 94 and 122%) and Cmax (1.53, 12.2 and 25.2 μM) following oral administration (10, 100 and 300 mg/kg) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

416.49

Formula

C₂₀H₂₄N₄O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PI3Kγ inhibitor 4
Cat. No.:
HY-132299
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