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PKG1α activator 3 

Cat. No.: HY-151203
Handling Instructions

PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM). PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research.

For research use only. We do not sell to patients.

PKG1α activator 3 Chemical Structure

PKG1α activator 3 Chemical Structure

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Description

PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM). PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research[1].

In Vitro

PKG1α activator 3 (11.7-33.3 μM; 45 min) shows phosphorylation of VASP[1].
PKG1α activator 3 (6.2-22.8 μM; 24 h) inhibits PDGF-induced cell proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Smooth muscle cells
Concentration: 6.2-22.8 μM
Incubation Time: 24 hours
Result: Inhibited hPASMC proliferation EC50 value of 6 μM.

Cell Viability Assay[1]

Cell Line: HEK 293 cells
Concentration: 11.7-33.3 μM
Incubation Time: 45 min
Result: Showed pVASP cell EC50 value of 13.4 μM.
In Vivo

PKG1α activator 3 shows acceptable in vivo rat pharmacokinetic profiles[1].

pharmacokinetic parameters
Compound Cl (mL/min/kg) Vd (L/kg) MRT (h) PPB (%)
PKG1α activator 3 8.1 0.45 0.9 >99.9

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

545.41

Formula

C27H26Cl2N2O6

SMILES

O=C(O)C1=CC=C(CN2[[email protected]@H](C3=CC=CC=C3)[[email protected]@H](O[[email protected]@H](C4=CC(Cl)=CC(Cl)=C4)CO)CCC2)C([N+]([O-])=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
PKG1α activator 3
Cat. No.:
HY-151203
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