PM050489 

PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC₅₀ value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research^[1][2].

Mitosis^[1]

PM050489 inhibits the activity of HT-29, A-549 and MDA-MB-231 cells with GI₅₀ values of 0.46 nM, 0.38 nM and 0.45 nM, respectively^[1].
PM050489 (0.01 nM and 0.1 nM; 24 h) destroys the morphology of microtubule networks and mitotic spindles in A549 cells^[2].
PM050489 (0.01, 0.1, 1 and 10 nM) inhibits tubulin polymerization with dose-dependent manner in A549 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

606.15

C₃₁H₄₄ClN₃O₇

960210-97-3

C/C(Cl)=C\C[C@H](OC(N)=O)C/C=C\NC([C@H](C(C)(C)C)NC(/C=C\C=C/C(C)=C/[C@@H]([C@@]1([H])OC(C(OC)=CC1)=O)C)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Martín MJ, et al. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J Am Chem Soc. 2013 Jul 10;135(27):10164-71.  [Content Brief]

  [2]. Pera B, et al. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.  [Content Brief]