1. TGF-beta/Smad
  2. TGF-β Receptor
  3. pm26TGF-β1 peptide

pm26TGF-β1 peptide 

Cat. No.: HY-P2294
Handling Instructions

pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

pm26TGF-β1 peptide Chemical Structure

pm26TGF-β1 peptide Chemical Structure

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Description

pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction[1][2].

IC50 & Target

TGF-β1 receptor[1][2]

In Vitro

The synthetic pm26TGF-β1 peptide (1 μM, 10 μM and 100 μM; 24-48 hours) tested in peripheral blood mononuclear cells (PBMC) significantly down-modulates TNF-α and up-regulates IL-10 responses in an inflammatory microenvironment, leading to regulatory T cells (Treg) phenotype differentiation[1].

In Vivo

pm26TGF-β1 peptide (100-1000 µg/kg; subcutaneous injection; once; male C57BL/6 mice) treatment decreases neutrophils migration during inflammatory process in C57BL/6 mice[1].

Animal Model: Male C57BL/6 mice (5-7-weeks old; 20-30g) injected with carrageenan[1]
Dosage: 100 µg/kg, 300 µg/kg or 1000 µg/kg
Administration: Subcutaneous injection; once
Result: Decreased neutrophils migration during inflammatory process in C57BL/6 mice.
Molecular Weight

1392.56

Formula

C₅₄H₉₃N₁₉O₂₀S₂

Sequence

Ala-Cys-Glu-Ser-Pro-Leu-Lys-Arg-Gln-Cys-Gly-Gly-Gly-Ser

Sequence Shortening

ACESPLKRQCGGGS

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

pm26TGF-β1 peptideTGF-β ReceptorTransforming growth factor beta receptorsLeukocytesrollingneutrophilsmigrationanti-inflammatoryα-helixTregTNF-αIL-10differentiationInhibitorinhibitorinhibit

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Product name:
pm26TGF-β1 peptide
Cat. No.:
HY-P2294
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